A bit more on
CLA. Still not particularly impressive.
J Nutr 2002 Nov;132(11):3272-9
linoleic Acid differentially modifies Fatty Acid composition
in subcellular fractions of muscle and adipose tissue but not
adiposity of post-weanling pigs.
Demaree SR, Gilbert
CD, Mersmann HJ, Smith SB.
Animal Science, Texas A&M University, College Station, TX
77843 and. U.S. Department of Agriculture/ARS Children's Nutrition
Research Center, Baylor College of Medicine, Houston, TX 77030.
This study examined
the interaction between conjugated linoleic acid (CLA) and dietary
fat type on the enrichment of subcellular fractions, the Delta-9-desaturase
index and adiposity in pigs. Early weaned piglets (n = 6/group)
were fed for 35 d diets supplemented with 15 g/100 g diet beef
tallow or corn oil, or 12 g/100 g tallow or corn oil plus 3 g
CLA. There were no effects of dietary fat or CLA on the mass
of dissected skin, bone, muscle or adipose tissue of the 7th
to 9th thoracic rib sections. Medial subcutaneous adipose tissue
of pigs fed tallow had smaller adipocytes than that of pigs fed
corn oil. The lateral subcutaneous site was unaffected by dietary
Microsomes accumulated <50%
the concentration of trans-10,cis-12, cis-11,trans-13, and cis-9,trans-11
CLA as membrane and non-membrane fractions of adipose tissue
and longissimus muscle. There was no evidence of preferential
incorporation of any CLA isomer into any of the subcellular fractions.
Addition of CLA to the diets reduced adipose tissue non-membrane
monounsaturated fatty acids (MUFA; g/100 g total fatty acids)
by 15% in corn oil-fed pigs and by 19% in tallow-fed pigs.
fatty acids (SFA) were increased by CLA commensurately in this
lipid fraction. This resulted in a reduced Delta(9) desaturase
index [MUFA/(SFA + MUFA)] in the non-membrane lipid fraction
of pigs fed either the corn oil or tallow diets. Thus, in spite
of marked effects on fatty acid composition and the Delta(9)
desaturase index, CLA had no effect on adiposity in early weaned
piglets fed high fat diets.